P-139 Comparison of cost-effectiveness of anti-epidermal growth factor receptor monoclonal antibody and anti-vascular endothelial growth factor monoclonal antibody in K-RAS WT, RAS WT, and RAS WT left-sided metastatic colorectal cancer
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چکیده
منابع مشابه
Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies in Metastatic Colorectal Cancer Biotherapy: A Systematic Review
The standard treatment of metastatic colorectal cancer (CRC) is combination of 5-fluorouracil/folinic acid (5-FU/FA) with irinotecan or oxaliplatin-based chemotherapy. Two anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (cetuximab and panitumumab) have been developed recently in an effort to provide yet another therapeutic option against mCRC. Cetuximab is a recombinant human...
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BACKGROUND In advanced colorectal cancer, K-Ras somatic mutations predict resistance to mAbs targeting epidermal growth factor receptor (EGFR). Relationships between K-Ras mutations and EGFR status have not been examined so far. We analyzed relationships between K-Ras mutations and EGFR tumoral status based on EGFR germinal polymorphisms, gene copy number and expression. METHODS Eighty colore...
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Angiogenesis plays a key role in tumor growth and metastasis. The transforming growth factor alpha (TGF-alpha)-epidermal growth factor receptor (EGFR) autocrine pathway controls in part the production of angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in cancer cells. In this study, we have evaluated the antiangiogenic and antitumor...
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Epidermal growth factor (EGF)-related proteins such as transforming growth factor alpha (TGF-alpha) control cancer cell growth through autocrine and paracrine pathways. Overexpression of TGF-alpha and/or its receptor (EGFR) has been associated with a more aggressive disease and a poor prognosis. The blockade of EGFR activation has been proposed as a target for anticancer therapy. Monoclonal ant...
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Human carcinomas frequently express one or more members of the epidermal growth factor receptor family. Two family members, epidermal growth factor receptor (EGFR) and c-erbB2/neu (HER2), homodimerize or heterodimerize upon activation with ligand and trigger potent mechanisms of cellular proliferation, differentiation and migration. In this study, we examined the effect of the anti-EGFR monoclo...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2020
ISSN: 0923-7534
DOI: 10.1016/j.annonc.2020.04.221